Machine learning-driven identification of drugs inhibiting cytochrome P450 2C9
Fig 3
Inhibition effect of sertindole, cloperidone, asapiprant, ticagrelor, duvelisib, dasatinib, bifeprofen and piriqualone on HepG2 cells expressing human CYP2C9.
The enzymatic activity with respect to the control is shown as a function of the drug concentration. HepG2 cells were treated with the drugs at the indicated concentrations for 24 h. Similar results were observed in three independent experiments. The bar graphs were obtained with GraphPadPrism v. 5.03 and represent mean ± SD of triplicate determinations.