The structural coverage of the human proteome before and after AlphaFold
Fig 3
Changes in structural coverage of biomedical proteins due to AlphaFold models.
a) Current structural coverage (y-axis) of different subsets of proteins (x-axis). Bars are colored according to the source of the structural coverage. b) Same as a but focusing on Clinvar mutations classified by their pathogenicity (x-axis). c) Same as a but focusing on somatic mutations from TCGA, classified by their likely oncogenicity (x-axis). d) Same as a but focusing on oncogenic mutations from BoostDM. e) AlphaFold model for B3GALT6. Residues are colored according to their pLDDT from red (lower values) to blue (higher values). Pathogenic mutations from Clinvar are highlighted in yellow. e) AlphaFold model for MED12. Coloring is the same as for d, but yellow residues indicate oncogenic mutations.