The structural coverage of the human proteome before and after AlphaFold
Fig 1
Current coverage of the human proteome.
a-b) Barplot showing the absolute (a) or relative (b) number of PDB coordinate files mapping to human proteomes at >95%, 95–50% and 50–20% thresholds of sequence identity. Legends in barplots a and b are the same. c) Evolution of the coverage of the human proteome by three-dimensional coordinate files in the Protein Data Bank (y-axis) according to the minimum percent identity of the BLAST hits (x-axis). Each line represents the coverage using only the coordinate files available in PDB in a given year. d) Barplot showing the coverage of the human proteome by different types of structural features, both linear (PFAM domains and IDRs) and three-dimensional (PDB) (y-axis is the same as in c). e) Coverage of the proteome by different AlphaFold pLDDT score thresholds (y-axis is the same as in c). f) Coverage (y-axis) of different types of regions (x-axis) depending on AlphaFold confidence levels. g) Current coverage (y-axis) of the human proteome.