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Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts
Fig 8
Bursting in the low initiation rate regime.
(A) shows the average inter-burst interval 
as a function of α with the headway distribution prediction for the average waiting time 
given by a dashed line. (B) shows the average burst size 
plotted as a function of α. Panels (A) and (B) were generated with Fig 5D–5F with α∈[0.001, 1] with hc = ho∈{0.0143, 0.033} to achieve γ∈{0.1, 0.2}. (C) shows that the variance of burst size 
(simulated) is equal to the variance of a geometric distribution given by Eq 46 and is colored by −log10 α. (D) compares the mean inter-burst interval and the variance of the inter-burst intervals to establish that the waiting time distribution is exponentially distributed using the data from Fig 5A–5C and is colored by −log10 γ. (E) and (F) show representative burst size probability mass functions generated from geometric distributions with means given by 
= 3.62 and 1.49 associated with the parameter sets (α = 0.01, γ = 0.2) and (α = 0.002, γ = 0.2).
doi: https://doi.org/10.1371/journal.pcbi.1009811.g008