RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins
Fig 2
(a) Direct Coexistence simulations of FUS/RNA (left) and scaffold proteins/RNA (right) using short RNA strands (top; 50-mer polyU and 10-bead RNA chains in the FUS and the minimal scaffold protein system respectively) and long RNA strands (bottom; 400-mer and 250-bead RNA chains in the FUS and the minimal scaffold protein system respectively) at T/Tc = 1.01, where Tc corresponds to the pure protein critical temperature of each system. (b) Direct Coexistence simulations of PR25/RNA (left) and cognate proteins/RNA (right) using both short RNA strands (top; 40-mer polyU and 10-bead polyU RNA chains in the PR25 and RNA cognate protein system respectively) and long RNA strands (bottom; 400-mer and 250-bead RNA chains in the PR25 and RNA cognate protein system respectively) at T/Tc = 1.01, where Tc corresponds to the pure critical temperature of FUS (left) and scaffold proteins (right), as in panel (a).