Known allosteric proteins have central roles in genetic disease
Fig 5
Conservation, mutation density, and disease associations of allosteric and non-allosteric proteins involved in disease.
Kinases and drug targets are shown separately. A-C) Allosteric proteins are characterised by a somewhat higher conservation than non-allosteric proteins. D-F) Allosteric proteins are characterised by significantly higher numbers of pathogenic mutations than non-allosteric ones. G-I) Despite having more pathogenic mutations, the relationship between the number of diseases, and the number of pathogenic mutations is qualitatively similar for allosteric and non-allosteric proteins.