A spatially resolved stochastic model reveals the role of supercoiling in transcription regulation
Fig 5
Intergenic supercoiling affects the level of mRNA production of two neighboring genes.
(A) The construct for convergently, divergently and codirectionally arranged genes with the intergenic length fixed at 1.2 kb. The mRNA copy number distribution (B) and intergenic supercoiling distribution (C) for cases with (orange bar) and without (blue bar) intergenic supercoiling. The bar plot for initiation rate (D) and elongation rate (E) for cases with (orange bar) and without (blue bar) intergenic supercoiling. Error bar suggests standard deviation.