Modeling cortical synaptic effects of anesthesia and their cholinergic reversal
Table 1
Parameter optimization for simulated anesthetic concentrations when performed on 10 different network realizations.
A/B-Series describe optimal values determined by the differential evolution algorithm fitting network connectivity parameters obtained when repeating the optimization for 10 total networks. Optimization includes A-Series, when ACh effects are assumed constant and B-Series, when ACh effects are allowed to change with anesthetic concentration. The scaling factors Px scale the effects of synaptic conductances mediated by the x receptor (x = NMDA, GABA and AMPA). A1-A4/B1-B4 denote optimal parameter sets fit to experimental recordings at varying anesthetic concentrations (0%, 2%, 4%, 6% desflurane, respectively). PAMPA is only fit for the 0% anesthetic case A1/B1. Error displayed is SEM.