Modeling cortical synaptic effects of anesthesia and their cholinergic reversal
Fig 8
Network structure is populated by lognormal distributed random connection strengths.
A). Synaptic strengths in model networks varied according to a lognormal distribution with a minority of connections being mediated by strong synaptic strengths, while weak synaptic strengths constitute majority of connections B) Simulated network consists of 200 inhibitory and 800 excitatory cells connected randomly with 10% probability. Connection color reflects the log of synaptic strength. C, D) Postsynaptic potential time courses in response to synaptic currents mediated by different receptors. Excitatory currents are modeled with both AMPA and NMDA mediated currents. Bottom panel shows timing of presynaptic spikes, for simplicity both inhibitory and excitatory presynaptic neurons are shown with the same spike times.