Modeling cortical synaptic effects of anesthesia and their cholinergic reversal
Fig 3
Firing rate distributions for different levels of anesthetic concentration.
A) Changes in experimentally recorded firing rate distributions under increasing desflurane concentration (0, 2, 4, and 6%) show increased right skewness for the awake state in comparison to anesthetic states. The bins were normalized by the total number of spikes relative to the awake case (0%). B) and C) Firing rate distributions in optimized networks for A- (B) and B- (C) series parameter sets. Simulated networks show similar trends in frequency distributions when compared to experiment. The predicted ACh-induced reversal shows reinstatement of the right skew. The bins were normalized by the total number of spikes relative to the awake case A1/B1. Upper/Lower bound show histogram standard error. Results based on lowest cost fit parameters.