Modeling cortical synaptic effects of anesthesia and their cholinergic reversal
Fig 1
Common inhalation anesthetics have similar effects on synaptic receptors.
Experimental findings show similar effects across inhalation anesthetics on synaptic receptors [29,30,38,92]. Binding to inhibitory GABAA receptors is commonly potentiated while NMDA receptor activity is commonly inhibited with the magnitude of effect varying between anesthetics. Activation of muscarinic acetylcholine receptors and AMPA receptors is inhibited by isoflurane and sevoflurane while desflurane has a biphasic effect and null effect on muscarinic acetylcholine and AMPA receptors, respectively.