Positional SHAP (PoSHAP) for Interpretation of machine learning models trained from biological sequences
Fig 6
SHAP dependence plots for allele Mamu-A001 show how relationships between sequential amino acids contribute to binding.
Each graph represents a pair of positions in the peptide, here (A) positions one and two and (B) positions two and three. The x-axis lists each possible amino acid for that position and the y-axis shows the SHAP value. Each point represents a peptide with the listed amino acid at that position on the x-axis and the amino acid in the subsequent position is shown by color. This shows how the range of SHAP values for a particular amino acid at a specific location is reflective of the dependence of other amino acid positions.