One-carbon metabolism during the menstrual cycle and pregnancy
Fig 6
Homocysteine throughout pregnancy.
Estradiol (E2) increases significantly from about 0.35 nM to 58.46 nM throughout pregnancy [7, 11]. The E2 data from [11] is reproduced in Panel B. Our model predicts Hcy throughout pregnancy as a result of E2 changes. Hcy is plotted relative to its concentration in menstruating women (red curve, Panel A). Our model corresponds well with data from [52], which is also plotted relative to Hcy in menstruating women (black dots, Panel A). The black bars indicate standard deviation.