One-carbon metabolism during the menstrual cycle and pregnancy
Fig 5
Effects of folate deficiency in the mathematical model.
For both males and females, vMS, the velocity of the MS reaction, is homeostatic until total folate gets below 30% of normal. As a result, the Hcy concentration does not depend strongly on total folate. As discussed in [12], the Vmax of the MS reaction is larger in females than in males, and as usual, the female Hcy concentration is below the male Hcy concentration. Both Hcy curves show the convex shape of the mean curves in the NHANES data in Fig 4a and 4b.