One-carbon metabolism during the menstrual cycle and pregnancy
Fig 3
One-carbon metabolism during the menstrual cycle.
Panel A shows the model concentrations of Met, SAM, SAH, and Hcy and the SAM/SAH ratio throughout the menstrual cycle, relative to their values at the beginning of the cycle. Panel B shows the model velocities of the MS, CBS, and AMD1 reactions, and the fraction of flux arriving from SAH that is transsulfurated. Panel C shows the model velocities of four important methyltransferases, GNMT, GAMT, DNMT, and PEMT. Finally, Panel D shows the relative model concentrations of 5mTHF and GSH, and the velocities of the TS and AICART reactions.