Combination treatment optimization using a pan-cancer pathway model
Fig 2
Single-step treatment for K029AX.
Comparison between optimized single-cell multi-drug treatment, optimal single-drug treatment, and optimal PD0325901/PLX-4720 combination treatment for K029AX—a melanoma cell line with BRAF V600E mutation—for three different types of regularization. Left plots: optimal treatment as identified by the objective function for different penalty parameters. The middle plots: relationship between administered total dosage and achieved proliferation value regardless of penalty and objective value. Right plots: composition of the multi-drug treatments. For all three types of regularization the optimization process leads to combination treatments which achieve significantly lower predicted proliferation values at lower concentrations than single and two-drug treatment. The treatment composition varies with the type of regularization.