Systematic evaluation of NIPT aneuploidy detection software tools with clinically validated NIPT samples
Fig 4
The effect of FF on detection of T21 across different sequencing coverages.
Ze cut-off was used for identifying the presence of the trisomy (internal classification in the case of GIPseq). Black triangles represent undetected trisomy cases. The 20M RPS group served as the standard for FF calculations. Data obtained with sequencing depths of 20M RPS (A), 15M RPS (B), 10M RPS (C), 5M RPS (D), 2.5M RPS (E), and 1.25M RPS (F) are shown.