Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies
Fig 3
a) The CDRH3 loops of nanobodies and antibodies of two binding regions, the ‘neck’ and ‘left flank’, binding to SARS-CoV-2 RBD (salmon). The ‘neck’ cluster includes 22 antibodies (red). The ‘left flank’ region includes five antibodies (the four antibodies identified by [28] are shown in orange, antibody MW06 is shown in magenta) and four nanobodies (shown in blue). MW06 and the nanobodies were not included in the analysis by [28]. See S1 and S2 Tables for antibody and nanobody PDB codes respectively. b) A ribbbon representation of sequence dissimilar antibodies S304 (blue) [PDB code 7L0N] and EY6A (green) [PDB code 6ZER, chain A] binding to the SARS-CoV-2-RBD (salmon) [PDB code 6ZER, chain B]. The CDRH1, CDRH2 and CDRH3 loops are illustrated in cartoon. The CDRH3 sequences of the two antibodies, S304 and EY6A, are shown, with dissimilar residues indicated in bold.