Extracting multi-way chromatin contacts from Hi-C data
Fig 4
Comparing many-body contact predictions with MC-4C.
(A) Comparing log10(pij) from Hi-C and HLM at 10-kb resolution of a 1.28 Mb region on chr8, where there are thirteen CTCF-binding sites labeled from A to M. The genomic position of forward- and backward-oriented CTCF sites are marked with red and blue sticks, respectively. (B, C) Comparing log10(pijk) from MC-4C and HLM at a viewpoint of site E and K, respectively. From the viewpoint of E (K), the values of PC between the model and the MC-4C experiment are 0.83 (0.81) and 0.71 (0.73) for the WT and ΔWAPL cells, respectively. (D) Cell-line difference of the predicted three-body contacts, namely , among the CTCF-binding sites from the viewpoint of A, E and (E) H, K, respectively. (F, G) Cell-line difference of four- and five-body contacts from double- and triple-anchored viewpoints, whose positions are marked with the black strips. The numbers label the maximum amplitudes of changes.