Extracting multi-way chromatin contacts from Hi-C data
Fig 3
Three-body contacts predicted with HLM versus those from Tri-C.
(A) Gene notation, DNase hypersensitive sites, CTCF-binding sites [59, 60] and genomic regions of interest (sites of interest, SOI) at mouse α-globin locus on chr11. (B) log10(pij) from Capture-C (top triangle) and HLM (bottom triangle) at 2-kb resolution. (C, D) log10(pijk) from Tri-C (top) and HLM (bottom) at k = R2 and k = HS-39, whose positions are labeled with black strips. The Pearson correlations between Tri-C and HLM are 0.80 (ES) and 0.75 (erythroid) for k = R2, and 0.89 (EC) and 0.85 (erythroid) for k = HS-39. (E) Cell-line difference of the predicted three-body contacts, , among the SOIs with respect to the viewpoints R2, HS-39 and (F) Hba-a1, HS+44.