Extracting multi-way chromatin contacts from Hi-C data

doi:10.1371/journal.pcbi.1009669

Extracting multi-way chromatin contacts from Hi-C data

Fig 2

Flow chart of HLM that is enclosed by the dashed orange box.

It takes two-body contacts from Hi-C as input, and calculates n-body (n > 2) contact probability. The stiffness matrix is updated until the algorithm finds that minimizes the cost function which quantifies the difference between pairwise contact probabilities of Hi-C data and those determined from matrix.

doi: https://doi.org/10.1371/journal.pcbi.1009669.g002