Extracting multi-way chromatin contacts from Hi-C data
Fig 1
Chain organization of chr3 of mouse ES cells measured in the DNA seqFISH+ experiment [24].
(A) 3D positions of 151 imaged loci spaced about 1 Mb apart (large empty dots) and 60 consecutive loci with an equal space of 25 kb (small solid dots) in one of 446 sample cells. (B) Angular correlation of the chromatin segments at 25 kb resolution. (C) Distribution of the physical distance of four loci pairs at 1 Mb resolution (markers) with their fittings to our theory (lines, Eq 3), which are rescaled by using the fitting parameter (γij) and plotted in the inset. (D) Rescaled pairwise distance distributions of all loci pairs, which are colored by their genomic lengths. (E, F) Similar as (C, D) but at 25 kb resolution.