Quantitative modeling identifies critical cell mechanics driving bile duct lumen formation
Fig 8
Simulation results for Model 3.
(A) lumen area versus time for different osmotic pressures. The solid lines are the average of 5 stochastic realizations of the same parameter set, while the shadowed regions indicate the minimum and maximum values of these realizations. (B-C) Snapshot of a simulation for Model 3 (PL = 50Pa and PL = 100Pa respectively). In B, the red zones indicate increased cell-cell adhesion due to presence of TJ. (D) Picture of typical bile duct lumen for an embryo at E18.5 (SOX9, blue; beta-catenin, green).