Quantitative modeling identifies critical cell mechanics driving bile duct lumen formation
Fig 7
Simulation results for Models 1 and 2.
(A) Immediately after the initial state, where a cholangiocyte divides in two daughter cells. The division direction is indicated by the arrow. (B) Snapshot of a simulation for Model 0 (t = 12). (C) Lumen area versus time for models 1 and 2, for different runs (no osmotic effects present). The solid lines are the average of 5 stochastic realizations of the same parameter set, while the shadowed regions indicate the two times standard deviation interval of these realizations. (D) Snapshot of a simulation for Model 1 (t = 12). (E) Snapshot of a simulation for Model 2 (t = 12). The red, grey and blue cells indicate hepatocytes, cholangiocytes and the mesenchyme respectively. (F) simulation snapshots for model 2 showing TP’s (yellow) and apical sites of the cholangiocytes (red).