Quantitative modeling identifies critical cell mechanics driving bile duct lumen formation
Fig 5
Possible mechanisms of lumen formation in a cell bi-layer.
(A) Cell division. 1: double layer of cells with 4 dividing cells (indicated by orange dashed line). Cell division goes along PCP. 2: random directed cell division. (B) Apical constriction on the same 4 cells. Note the wedge-like shape of the four center cells with apical membrane marked in red in configuration 2 compared to configuration 1. (C) Osmosis initiated by 4 cells inducing hydrostatic pressure in extracellular space.