Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations
Fig 2
Genetic differentiation of African populations.
A) Sampling locations of the TB-DAR WGS cohort and populations within the AFGR reference panel, which includes the Sub-Saharan African populations of the 1000 Genomes (1KG) project. Line colors illustrate the degree of differentiation (FST) between TB-DAR and 1KG populations. B) Pairwise FST measures between 1KG populations and TB-DAR. 1000 Genomes Populations: GWD—Gambian in Western Divisions in the Gambia; MSL—Mende in Sierra Leone; YRI—Yoruba in Ibadan, Nigeria; ESN—Esan in Nigeria; LWK—Luhya in Webuye, Kenya. The map was created programmatically in R using the spData package [58], with the base layer based on public domain maps from Natural Earth (https://www.naturalearthdata.com/).