A systems genomics approach uncovers molecular associates of RSV severity
Fig 3
Integration of different data modalities improves prediction of GRSS.
The panel on the left shows the difference between the predicted and observed GRSS for a model that integrates the nasal epithelial transcriptome, peripheral blood CD4 transcriptome, and nasal microbiome, as well as for models using just one of these data types. Similarly, the panel on the right compares a model that integrates the transcriptomes of 3 immune cell types measured in peripheral blood with models using just one of these data types. In both cases, integration increases the precision of the GRSS predictions.