A systems genomics approach uncovers molecular associates of RSV severity
Fig 2
Five potential methods of multi-omic data integration.
Methods differ in their handling of nasal microbiome data (OTU), number of levels of PCA, and the stage at which the integration occurs. Here light purple circles represent nasal gene expression profiles (NT), light blue ones represent CD4 gene expressions, and gold ones represent nasal microbiome abundance data (OTU). Dark blue ones are principal components (PCs) computed from the original features. Large white circle represents the GRSS, which is the clinical variable of interest of this study. In our assessments, the leftmost model out-performed the other models in terms of cross-validated error.