Modelling novelty detection in the thalamocortical loop
Fig 6
Sensitivity of novelty-predicting effects to inter-stimulus intervals (ISI) tested in sequenced v.s. randomized paradigms.
(A) Illustration of sequenced and randomized stimulation trains and the stimulated whiskers. In two sequences, the delivery of the deviant stimulus to the C1 whisker is the same, but three standard stimuli are employed either periodically (sequenced condition, top) or randomly (randomized condition, bottom) to C2, D1 and B1 whiskers. The stimulus duration is 10 ms and deviant stimuli constitute 3% of overall stimuli (30 out of 1000 stimuli). (B) Early and late CSIs are respectively computed within time windows of 40 ms after stimulus onset and the remaining time before the onset of the next stimulus. The mean deviant responses in the CSI are averaged over 30 deviants out of 1000 stimuli in each paradigm. (C) Similarly, early and late CSIs are computed individually for the C1 deviant occurring right after the B1, C2 and D1 standards in the sequenced condition. The mean responses to each deviant type are averaged over 10 deviants out of 1000 stimuli. Each condition is repeated 5 times with different random seeds to calculate the mean and variant of the CSI values.