Control of tissue homeostasis, tumorigenesis, and degeneration by coupled bidirectional bistable switches
Fig 5
Effect of intrinsic and extrinsic noise on tissue state transitions.
(A) The steady 2-D distribution of N, S, and YTup from 1000 samples of stochastic simulations by increasing or decreasing kYTup0 value from the standard value kYTup0 = 0.007 that corresponds to the homeostatic state. (B) The steady 1-D distributions of YTup from 1000 samples of stochastic simulations with only intrinsic noises (left), or both extrinsic and intrinsic noises (right).