A conserved expression signature predicts growth rate and reveals cell & lineage-specific differences
Fig 2
Slow-proliferating ESCs display a more naive pluripotent stemness character than fast-proliferating ESCs.
(A) Comparison of lineage commitment-related gene expression between fast and slow proliferating subpopulations. (B) Comparison of pluripotency-associated gene expression between fast and slow proliferating subpopulations. (C) Comparison of 2C-like state markers expression between fast proliferating subpopulation and slow proliferating sub-population. Dashed lines separate genes expressed preferentially in slow- (left of dashed line) or in fast-proliferating (right of dashed line) ESCs. P-values are from binomial tests, testing if genes are more often highly expressed in slow cells than would be expected by chance (53.5% of all genes are more highly expressed in slow cells).