Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones
Fig 6
Registry predictions for forward-binding substrates.
For each substrate, the Paladin scores are shown for all possible binding registries that allow all five sites on DnaK to be occupied. Both backbone orientations are considered (forward: blue; reverse: orange). The registries as observed in the PDB structures are shown with blue stars. Note that the NRLLLTG peptide has been crystallized in two registries (PDB: 1DKZ, 4EZW).