GPRuler: Metabolic gene-protein-reaction rules automatic reconstruction
Fig 6
Evaluation of GPRuler performance by a comparison with in silico deletions of Yeast 8 genes.
Panel A shows on the left the confusion matrix resulting from the simulation of all the genes of the original model (labelled as “Original”), and on the right the confusion matrix created from the Yeast 8 GPRs reconstructed by GPRuler (labelled as “GPRuler”). Panel B shows the confusion matrix in the “Original” (on the left) and “GPRuler” (on the right) model when only genes involved in Yeast 8 reactions classified as “Corrected by GPRuler” are considered. The two labels V and N correspond, respectively, to the “Viable” and “Not viable” phenotype. Each cell of the confusion matrix is coloured according to the relative frequency of the corresponding case, which is shown in the middle of the cell, following the color scale reported on the right of each plot.