Approximate distance correlation for selecting highly interrelated genes across datasets
Fig 7
Biological functions and network analysis of highly interrelated genes selected by ADC across modalities.
(A) Schematic diagram shows the work flow of performing ADC on the scRNA-seq data and scATAC-seq data (FDR = 0.20). We first converted the scATAC-seq data to a predicted gene expression matrix. Specifically, we constructed a “gene activity matrix” from scATAC-seq dataset by utilizing the reads at gene body and 2kb upstream, then ADC was applied to a pseudo gene expression data and a real one. (B) The top enriched functional terms of the genes selected by ADC. (C) The gene network constructed with GeneMANIA using the top genes selected by ADC.