State transitions through inhibitory interneurons in a cortical network model
Fig 7
Interneuron properties and PC gain modulation.
A) A network with a homogeneous FS interneuron population was developed to explore the role of interneuron synaptic properties upon PC gain. B) Histogram of FS-to-PC synaptic latencies before (purple, ‘FS’) and after (green, ‘NFS’) modification to resemble NFS latencies. Connectivity and synaptic distribution were modified in a similar manner. C) Example of normalised average population response to the perturbation (arrow) following modification of interneuron latency. C) Estimated effective PC synaptic weight (BEWEE) within the FS network after modifying interneuron properties to resemble the NFS population (100% represents NFS values). An increase in estimated BEWEE was observed across all parameters, and at 100% latency and connectivity generated a significant change compared to baseline (P < 0.01, Welch’s t test).