State transitions through inhibitory interneurons in a cortical network model
Fig 6
PC gain modulation in the spiking network.
A) Raster plot of PC spiking (spikes denoted in red) and average population response (top trace, grey) in response to a brief stimulus applied to 20% of the PC population (black arrow). The stimulus elicited a bi-modal population response: the first peak (P1) in response to the stimulus and the second peak (P2) from PC-to-PC interactions. The effective synaptic weight was estimated by calculating the ratio of the area under the curves of P2 (yellow) to P1 (blue). B) Estimated effective synaptic weight (BEWEE) under conditions of increased FS and NFS rheobase. FS rheobase increased BEWEE above 1, consistent with excitatory subnetwork instability, and produced a significant increase in BEWEE compared to NFS rheobase (P < 0.001). C) Examples of normalised average population response to the perturbation (arrow) following increased FS rheobase.