A particle-based computational model to analyse remodelling of the red blood cell cytoskeleton during malaria infections
Fig 6
Effect of KAHRP clusters in actin-spectrin network.
(A) Snapshots of equilibrated networks for the interaction energies indicated above each image. KAHRP particles are shown in grey and some KAHRP clusters are indicated by rectangles and shown as zoom-ins. G-actin particles are not shown here. (B) Fraction of clusters that are located at actin filaments in contrast to other cytoskeletal subunits. The value is calculated for different interaction energies with actin and ankyrin. (C) Shear response of KAHRP containing networks for different KAHRP positioning. (D) A simple spring model was set up to understand the shear-reasponse of the KAHRP-containing cytoskeletal networks. (E) The effective spring constant is plotted according to our spring model.