Chemotherapy-induced cachexia and model-informed dosing to preserve lean mass in cancer treatment
Fig 11
Treatment efficacy for metronomic chemotherapy schedules administering 168 mg/kg/week over 1, 2, 3, 4, 5, or 6 equal, and equally spaced, daily doses.
Treatment efficacy is measured against the 24 mg/kg daily regime and the 35 mg/kg (5-on, 2-off) regime is included for reference. (A) The AUC ratio for lean mass compares the lean mass response from the tested schedule to that of the 24 mg/kg daily schedule. (B) The AUC ratio for tumour volume compares tumour volume response from the tested schedule to that of the 24 mg/kg daily schedule. (C) The total therapeutic efficacy is the ratio of the lean mass AUC ratio to the tumour volume AUC ratio.