Chemotherapy-induced cachexia and model-informed dosing to preserve lean mass in cancer treatment
Fig 6
Parameter sensitivity analysis for parameter τ using a 35 mg/kg daily (Left: A, B, C) or 49 mg/kg (5-on, 2-off) (Right: D, E, F) chemotherapy schedule to deliver a 245 mg/kg weekly dose. The nominal value is τ = 8. In (A) and (D) the value of τ is increased or decreased by 10% and the resulting lean mass is shown. The sensitivity coefficients (B and E) and relative sensitivity coefficients (C and F) are computed with a 0.001% change to the nominal value. Chemotherapy is applied over the first 28 days.