Construction of disease-specific cytokine profiles by associating disease genes with immune responses
Fig 10
SLE subnetwork formed between pathogenesis genes (green and purple) and inflammatory responses (orange, red, blue). The graph was plotted using a force-directed layout that uses attractive forces between adjacent nodes and repulsive forces between distant nodes. The distances between two vertices are roughly proportional to the length of the shortest path between them. Six genes (ACKR3, HRH4, HTR1, GAL, GRM3, S1PR1) in Box-C are making high degree contacts with the chemokine core (red box), with ANXA1 interacting with 16 chemokines. Interactions with the inflammation core (orange box) appear in multiple directions. Seven pathogenesis genes (Box-I-1) interact with the inflammation core (orange box) directly or through receptors (green nodes). Nine disease genes in Box-I-3 form a small core with four cytokines (IL18, IL22, IL1A and IL1B). Two other groups of genes (Box-I-2 and Box-I-4) appear distant from the cytokine core but are linked to the TNFs, as they cannot overcome the repulsive force to association with the center of inflammation responses.