Construction of disease-specific cytokine profiles by associating disease genes with immune responses
Fig 4
The 126 cytokines form six clusters based on their Association Scores with the 14,581 non-cytokine genes.
The six clusters are named after their most enriched types of cytokines: TGF-CLU (growth factors), Chemokine-CLU (chemokines), TNF-CLU (TNFs), IFN-CLU (interferons), IL-CLU (interleukins), and Unclassified-CLU. Based on the dendrogram of the hierarchical cluster tree, we identified six gene sets (SIG1-SIG6) that associate with the six individual clusters and two gene sets (BLU1, BLU2) that do not interact with the three major clusters (Chemokine-CLU, IFU-CLU, IL-CLU). Details of cytokines and signatures are in Tables 1–4.