Tumor cell intrinsic and extrinsic features predict prognosis in estrogen receptor positive breast cancer
Fig 2
Gene signatures recapitulate the downstream pathways of mutated driver genes.
a Spearman correlation coefficients (Correlation) between different gene signatures defined based on the TCGA ER+ breast cancer data. Signature scores can distinguish ER+ breast cancer samples with TP53_mut (b), ERBB2_amp (c), PIK3CA_mut (d), and GATA3_mut (e) from samples without the aberrations. b, c were based on the Curtis data; (d) was based on GSE41994; and (e) was based on GSE101780. ROC curves showing that TP53_mut (f) and ERBB2_amp (g) signature scores can predict the mutation status of their respective driver genomic aberration.