Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits
Fig 6
Heritability is proportional to the number of causal SNPs in a region.
We show the relationship between the number of causal SNPs and heritability for each region across height and diastolic blood pressure. We fit a linear regression for each trait and report the slope of the regression, which can be interpreted as the increase of heritability per additional causal SNP. Horizontal error bars represent two posterior standard deviations around our estimates for the number of causal SNPs. Vertical error bars represent twice the standard error around the estimates of regional heritability. Dots in black denote outlier regions which have an absolute studentized residual larger than 3.