Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits
Fig 4
BEAVR is computationally efficient.
(A) We show the run-time in terms of seconds per iteration of the Gibbs sampler (log-scale). We compare the version of BEAVR with the algorithmic speedup outlined in Materials and methods (‘speedup’) versus the straightforward implementation (‘baseline’). We vary the number of SNPs in the region while fixing the polygenicity of each region to pr = 0.01. (B) We show the runtime of the sampler when the number of SNPs in the region is fixed to M = 1, 000 and we vary the polygenicity.