Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits

doi:10.1371/journal.pcbi.1009483

Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits

Fig 2

BEAVR is relatively unbiased across various genetic architectures.

We ran 100 replicates where we vary the genome-wide heritability to be , 0.25, 0.5, the polygenicity of the region to be p_r = 0.005, 0.01, 0.05, 0.10, and the sample size N = 50K, 500K, 1 million individuals. We compared BEAVR to GENESIS-M2 (2-component) and GENESIS-M3 (3-component). The x-axis denotes the simulated values for the regional polygenicity and the y-axis denotes the estimated values across 100 replicates. Dashed red lines denote the true regional polygenicity value in each setting.

doi: https://doi.org/10.1371/journal.pcbi.1009483.g002