Time to revisit the endpoint dilution assay and to replace the TCID50 as a measure of a virus sample’s infection concentration
Fig 8
Impact of the choice of prior on the posterior distribution for ℓCinf.
A: Non-normalized priors for log10(specific infections, SIN/mL) = ℓCinf that are uniform in either Cinf or ℓCinf are shown. A prior uniform in Cinf is biased towards larger values of ℓCinf. B: Updated posterior belief about ℓCinf for each of the two prior beliefs shown in A, as per Eqs (7) and (8), after having observed the ED assay example provided in Fig 1. While the prior uniform in Cinf yields a posterior with a mode of ℓCinf = 6.21, that for a prior uniform in ℓCinf yields a mode of ℓCinf = 6.18.