A metric for evaluating biological information in gene sets and its application to identify co-expressed gene clusters in PBMC
Fig 4
Validating the metric using known gene modules and the k91 DICE clusters.
A. The GECO metric values evaluating the cluster quality for three sets of clusters; the 2008 BTMs, the 2019 BTMs, and the k91 DICE clusters. The ground truth set used to score the different cluster groups was the “Burel” 74-gene CD4 T-cell TB signature. The error bar on the k91 DICE clusters indicate the range of potential scores from the other 9 iterations of the k91 DICE clusters. B. The GECO metric values evaluating the cluster quality of the same three cluster sets as before. The ground truth set used to score the clusters was the “Berry” 393-gene whole blood TB signature.