Experimental and computational investigation of enzyme functional annotations uncovers misannotation in the EC 1.1.3.15 enzyme class
Fig 4
Exploration of functional annotation throughout all BRENDA enzyme classes.
(A) The total number of representative protein sequences (after clustering at 90% identity) annotated to EC classes in BRENDA, which is approximately 5.3 million. (B) The total number of experimentally characterised/curated enzymes. (C) Histogram showing the number of characterised/curated enzymes per EC class (bin size of 1). Histograms showing the distribution of sequence identities between all 5.3 million cluster representatives and their closest characterised/curated enzyme for Archaea (D), Bacteria (E), and Eukaryota (F) (with a bin size of 1). Proteins which do not have the same Pfam domains as characterised/curated enzymes are coloured in grey.