Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits
Fig 7
Acetylcholine speeds up ensemble formation and lowers input frequency requirement by increasing cellular excitability.
A) Network setup: A population of excitatory and inhibitory cells connected in all-to-all fashion. Subpopulations of excitatory cells receive independent feed-forward input that drives ensemble formation. B) Example weight matrix driven by input with 30 Hz bursts in the presence of NA, 20 Hz bursts in the presence of NA or 20 Hz bursts in the presence of acetylcholine. Stronger weights indicate robust ensemble formation. C) Evolution of ensemble formation illustrated by the weight matrix error reduction over time for different input burst frequencies. Triangles denote which effects of acetylcholine on the CA3 network were included in each set of simulations.