Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits
Fig 6
Carbachol but not noradrenaline enhances CA3 cellular excitability and depresses associational/commissural synaptic connections.
A) 5 μM CCh depresses associational/commissural evoked EPSCs. Top: Example traces before and after bath application of 5 μM CCh. Bottom: Time course of CCh effect, and washout (n = 4). B) 20 μM NA has no effect on associational/commissural evoked EPSCs. Top: Example traces before and after bath application of 20 μM NA. Bottom: Time course of NA effect, and washout (n = 5). C) 5 μM CCh but not 20 μM NA depresses associational/commissural evoked EPSCs and increases paired pulse ratio (PPR). D) 5 μM CCh but not 20 μM NA depolarizes CA3 pyramidal cell membrane potential and increases input resistance.